Does the linear transcript function as a ceRNA for Sry miR-138? The sense of antisense [version 2; referees: 2 approved]

Recently, the sex determining region Y ( ) and the cerebellar Sry degeneration-related protein 1 ( ) RNA transcripts have been described CDR1as to function as a new class of post-transcriptional regulatory RNAs that behave as circular endogenous RNA sponges for the micro RNAs (miRNAs) miR-138 and miR-7, respectively. A special feature of the gene is its ability to Sry generate linear and circular transcripts, both transcribed in the sense orientation. Here we remark that both sense (e.g. RNA) and antisense (e.g. Sry ) transcripts could circularize and behave as miRNAs sponges, and CDR1as importantly, that also protein-coding segments of mRNAs could also assume this role. Thus, it is reasonable to think that the linear sense transcript could Sry additionally act as a miRNA sponge, or as an endogenous competing RNA for miR-138. Guillermo Aquino-Jarquin ( ) Corresponding author: [email protected] Granados-Riveron JT and Aquino-Jarquin G. How to cite this article: Does the linear transcript function as a ceRNA for miR-138? The Sry 2014, :90 (doi: ) sense of antisense [version 2; referees: 2 approved] F1000Research 3 10.12688/f1000research.3872.2 © 2014 Granados-Riveron JT and Aquino-Jarquin G. This is an open access article distributed under the terms of the Copyright: Creative , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly Commons Attribution Licence cited. Data associated with the article are available under the terms of the (CC0 1.0 Creative Commons Zero "No rights reserved" data waiver Public domain dedication). Work in the group’s lab is supported by grants CB-168661 from the Mexican Council of Sciences and Technology (CONACyT) Grant information: and Mexican Federal Funds (HIM/2012/010-SSA 1017). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: No competing interests were disclosed. 11 Apr 2014, :90 (doi: ) First published: 3 10.12688/f1000research.3872.1 Referee Status: